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Department of Cell & Tissue Biology
513 Parnassus Avenue, HSW-615/618
San Francisco, CA 94143-0512

last updated 8/2013
Complete list of publications on MyBibliography

2011 - present

Basu S., S.Sladecek, H.Pemble, T. Wittmann, J.A. Slotman, W. van Cappellen , H.R. Brenner, N. Galjart (2014) Acetylcholine receptor (AChR) clustering is regulated both by glycogen synthase kinase 3β (GSK3β)-dependent phosphorylation and the level of CLIP-associated protein 2 (CLASP2) mediating the capture of microtubule plus-ends. J Biol Chem. 289:30857-30867.

Liz M.A., F.N. Mar, T.E. Santos, H.I. Pimentel, A.M. Marques, M.M. Morgado, S. Vieira, V.F. Sousa, H. Pemble, T. Wittmann, C. Sutherland, J.R. Woodgett, M.M. Sousa (2014) Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2. BMC Biol. 12(1):47.

Stehbens S.J., M. Paszek, H. Pemble, A. Ettinger, S. Gierke, and T. Wittmann (2014) CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover. Nat Cell Biol 16:558-573.

Juang B.T., A.L. Ludwig, K.L. Benedetti, C. Gu, K. Collins, C. Morales, A. Asundi, T. Wittmann, N. L'Etoile, and P.J. Hagerman (2014) Expression of an expanded CGG-repeat RNA in a single pair of primary sensory neurons impairs olfactory adaptation in C. elegans. Hum Mol Genet. 23:4945-4959.

Tran C.S., Y. Eran, T.R Ruch, D.M Bryant, A. Datta,P. Brakeman, A. Kierbel, T. Wittmann, R.J. Metzger, K.E. Mostov, and J.N. Engel (2014) Host Cell Polarity Proteins Participate in Innate Immunity to Pseudomonas aeruginosa Infection. Cell Host Microbe 15(5):636-643.

Waters J.C., and T. Wittmann (2014) Concepts in Quantitative Fluorescence Microscopy. Methods Cell Biol 123:1-18.

Ettinger A., and T. Wittmann (2014) Fluorescence Live Cell Imaging. Methods Cell Biol 123:77-94.

Stehbens S.J., and T. Wittmann (2014) Analysis of Focal Adhesion Turnover: A Quantitative Live-Cell Imaging Example. Methods Cell Biol 123:335-346.

Moon H.M., Y.H. Youn, H. Pemble, J. Yingling, T. Wittmann and A. Wynshaw-Boris (2014) LIS1 controls mitosis and mitotic spindle organization via the LIS1-NDEL1-dynein complex. Hum. Mol. Genet. 23:449-466

Lyle K.S., J.A. Corleto, and T. Wittmann (2012) Microtubule dynamics regulation contributes to endothelial morphogenesis. Bioarchitecture 2:220-227.

Zhao X., P. Kumar, S. Shah-Simpson, K.L. Caradonna, N. Galjart, C. Teygong, I. Blader,
T. Wittmann, and B.A. Burleigh (2012) Host microtubule plus-end binding protein CLASP1 influences sequential steps in the Trypanosoma cruzi infection process.
Cell. Microbiol. 15:571–584

Stehbens S., and T. Wittmann (2012) Targeting and transport: how microtubules control focal adhesion dynamics. J. Cell Biol. 198:481-489.

Kumar P., and T. Wittmann (2012) +TIPs: SxIPping along microtubule ends.
Trends Cell Biol. 22:418-28.

Faculty of 1000 recommendedGierke S., and T. Wittmann (2012) EB1-recruited microtubule +TIP complexes coordinate protrusion dynamics during 3D epithelial remodeling. Curr. Biol. 22:753-762.

Kumar P., M.S. Chimenti, H. Pemble, A. Schönichen, O. Thompson, M.P. Jacobson,
and T. Wittmann (2012) Multisite phosphorylation disrupts arginine-glutamate salt bridge networks required for binding of cytoplasmic linker-associated protein 2 (CLASP2) to end-binding protein 1 (EB1). J. Biol. Chem. 287:17050-17064.

Stehbens S., H. Pemble, L. Murrow, and T. Wittmann (2012) Imaging intracellular protein dynamics by spinning disk confocal microscopy. Methods Enzymol. 504:293-313.

Haynes J., J. Srivastava, N. Madson, and T. Wittmann, D.L. Barber (2011) Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression. Mol. Biol. Cell. 22:4750-64.

Elwell C.A., S. Jiang, J.H. Kim, A. Lee, T. Wittmann, K. Hanada, P. Melancon, and J.N. Engel (2011) Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. PLoS Pathog. 7:e1002198.

2005 - 2010

Matov A., K. Applegate, P. Kumar, C. Thoma, W. Krek, G. Danuser, and T. Wittmann (2010) Analysis of microtubule dynamic instability using a plus-end growth marker. Nature Methods 7:761-768.

Gierke S., P. Kumar, and T. Wittmann (2010) Analysis of Microtubule Polymerization Dynamics in Live Cells. Methods Cell Biol. 97C:15-33.

Kumar P., K.S. Lyle, S. Gierke, A. Matov, G. Danuser, and T. Wittmann (2009) GSK3β phosphorylation modulates CLASP-microtubule association and lamella microtubule attachment. J. Cell Biol. 184:895-908.

Lyle K., P. Kumar, and T. Wittmann (2009) SnapShot: Microtubule Regulators I + II.
Cell 136:380, Cell 136:566.

Wittmann T. (2008) EBs clip CLIPs to growing microtubule ends. J. Cell Biol. 183:1183-1185.

Delorme V., M. Machacek, C. DerMardirossian, K.L. Anderson, T. Wittmann, D. Hanein, C. Waterman-Storer, G. Danuser, and G.M. Bokoch (2007) Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks.
Dev Cell. 13:646-662

Kita K., T. Wittmann, I.S. Näthke, and C.M. Waterman-Storer (2006) APC on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.
Mol. Biol. Cell. 17:2331-2345.

Wittmann T., and C.M. Waterman-Storer (2005) Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3β in migrating epithelial cells. J. Cell Biol. 169:929-939.
Correction in J. Cell Biol. 171:393.

Before 2005

Shirasu-Hiza M., Z.E. Perlman, T. Wittmann, E. Karsenti, and T.J. Mitchison (2004) Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked. Curr. Biol. 14:1941-1945.

Brunet S., T. Sardon, T. Zimmerman, T. Wittmann, R. Pepperkok, E. Karsenti and I. Vernos (2004) Characterization of the TPX2 domains involved in microtubule nucleation and spindle assembly in Xenopus egg extracts. Mol. Biol. Cell. 15:5318-5328.

Wittmann T., R. Littlefield and C.M. Waterman-Storer (2004) Fluorescent Speckle Microscopy of cytoskeletal dynamics in living cells. In Live Cell Imaging: A Laboratory Manual. D. L. Spector and R. D. Goldman, editors. Cold Spring Harbor Press, New York, pp 187-204.

Wittmann T. and C.M. Waterman-Storer (2004) Regulation of microtubule dynamics in migrating cells: A new role for Rho GTPases. In Cell Motility: From molecules to organisms. A. Ridley, M. Peckham, and P. Clark, editors. John Wiley and Sons, London. pp 203-213.

Wittmann T., G.M. Bokoch and C.M. Waterman-Storer (2004) Regulation of Op18/stathmin's microtubule-destabilizing activity downstream of Rac1. J. Biol. Chem. 279:6196-6203.

Wittmann T., G.M. Bokoch and C.M. Waterman-Storer (2003) Regulation of leading edge microtubule and actin dynamics downstream of Rac1. J. Cell Biol. 161:845-851.

Adams M.C., W.C. Salmon, S.L. Gupton, C.S. Cohan, T. Wittmann, N. Prigozhina and C.M. Waterman-Storer (2002) A high-speed multi-spectral spinning disc confocal microscope system for fluorescent speckle microscopy of living cells. Methods 29:29-41.

Andersen S.S.L. and T. Wittmann (2002) Toward reconstitution of in vivo microtubule dynamics in vitro. Bioessays 24:305-307.

Wittmann T. and C.M. Waterman-Storer (2001) Cell motility: can microtubules and Rho GTPases point the way? J. Cell Sci. 114:3795-803.

Wittmann T., A.A. Hyman and A. Desai (2001) The spindle: A dynamic assembly of microtubules and motors. Nature Cell Biol. 3:E28-E34.

Wittmann T., M. Wilm, E. Karsenti and I. Vernos (2000) TPX2, a novel Xenopus MAP involved in spindle pole organization. J. Cell Biol. 149:1405-1418.

Ahmad F.J., J. Hughey, T. Wittmann, A. Hyman, M. Greaser and P.W. Baas (2000) Motor proteins regulate force interactions between microtubules and microfilaments in the axon. Nature Cell Biol. 2:276-280.

Wittmann T. and T. Hyman (1999) Recombinant p50/dynamitin as a tool to examine the role of dynactin in intracellular processes. In Methods in Cell Biology. Vol. 61. C. Rieder, editor. Academic Press, San Diego. pp 137-143.

Wittmann T., H. Boleti, C. Antony, E. Karsenti and I. Vernos (1998) Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein. J. Cell Biol. 143:673-685.

Wittmann T. and E. Wahle. (1997) Purification and characterization of full-length mammalian poly(A) polymerase. Biochim. Biophys. Acta 1350:293-305.